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Featured Device

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Product Code: SONIDEL SP100

Desc:Sonoporator
Applic:(hover for application)Application:
  • Delivery of plasmids to cells and tissues for gene therapy-based applications and studies.
  • Delivery of nucleic acids such as siRNA, RNAi etc. to cells and tissues for studies on control of gene expression/gene therapy.
  • Delivery of cancer chemotherapeutic agents to impermeable target cells/tissues.
  • Delivery of agents to cells to study metabolic effects.


Featured Electrode



Product Code: CUY530G2

Application:
Electrodes for Electro Cell Fusion
Description:
Gold blocks on petridish, 2mm gap, 40ul volume

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Electrochemotherapy for digital chondrosarcoma

Electrochemotherapy for digital chondrosarcoma


NEPA21 / CUY21 Applications

[Cancer Therapy] Electrochemotherapy for digital chondrosarcoma.

Swolen proximal phalanx of the middle finger.jpg

a.     Proximal phalanx of the middle finger is swollen.

b.   Expanding radiolucent mass in the proximal phalangeal bone.

c.     No recurrence was seen even 3 years after treatment.

.

Biopsy specimen.jpg

Biopsy specimen.

a) Cells varying in size and shape with nuclear atypia and multivesicular vacuolation of cytoplasm.

b) Two weeks after electrochemotherapy, histological analysis of core needle biopsies revealed 90% tumor cell necrosis

H&E x 200

.


.

Electrode and electroporation.

a. Stainless steel 3cm x 5cm electrodes.

b. Electroporation with two parallel

electrodes placed on opposite

sides of the tumor

Resistance Measurement:     245±101

Voltage: 150V (Electric field strength: 50/cm)

Current:   1.1±0.5A

Pulses:

4 pulses of 250ms (On: 50ms, Off: 200ms)

Or

6 pulses of 167ms (On: 50ms, Off: 117ms)

Gross and microscopic findings of the resected tumor.

a) Gross appearance of marginally resected tumor.

b) Cut surface.

c) Microphotograph of the central portion of the tumor (area c in panel b).

d) Peripheral region (area d in panel b).

H&E x 200

A histological study of the resected tumor showed necrosis at the tumor margin.

Department of Orthopedic Surgery, Shinshu University School of Medicine; Tominaga Shimizu

Department of Regenerative Medicine, Toyama Medical and Pharmaceutical University; Toshio Nikaido

*Journal of Orthopaedic Science, Volume 8, Number 2, Pages 248-251, March 2003

.

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