SONIDEL SDM-Series Range of Microbubbles
New Microbubble Range for Ultrasound-mediated Gene Transfer
Please note that the SONIDEL MB101 Microbubble has been discontinued and replaced with the superior SONIDEL SDM®-series range of microbubbles.
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SDM®-Series Microbubbles from SONIDEL
Introducing the largest range of Mcrobubbles optimised for Ultrasound-mediated Transfection for Research Applications.
In Vitro and In Vivo
Supporting:
- Antibody Coupling
- Nucleic Acid Loading
- Drug Loading
Our Range of Microbubbles are:
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* State-of-the-art and not available from any other supplier * Polymer-stabilized, lipid-based microbubbles * PEGylated surface for long shelf life, stability in circulation and reduced non-specific binding * Optimized for use with the SONIDEL SP100 sonoporator and Gene Transfer applications * Efficient gene/nucleic acid transfer, in vitro and in vivo * Ideal as a nucleic acid and drug carrier – increased payload capacity * Minimal impact on cell/tissue viability * The smallest sized bubbles on the market
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We can custom manufacture microbubble preparations to client specification. (This service is only available to clients who have purchased the SP100 Sonoporation Platform)
Our New Microbubble Portfolio:
Group |
Code |
Get Quotation** |
Nature |
Average diameter (µm) |
Reference |
Conventional pegylated |
SDM201® |
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Neutral | 1.7 | Nomikou et al., 2011* |
| SDM202® |
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Cationic | 1.7 | Nomikou et al., 2011* | |
| SDM203® |
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Anionic | 1.7 | Not available | |
Biotinylated pegylated |
SDM301® |
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Biotinylated Neutral | 1.7 | Not available |
| SDM302® |
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Biotinylated Cationic | 1.7 | Nomikou et al., 2011* | |
| SDM303® |
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Biotinylated Anionic | 1.7 | Not available |
* Publication:
‘Studies on neutral cationic and biotinylated cationic microbubbles in enhancing ultrasound-mediated gene delivery in vitro and in vivo‘
Acta Biomater. 2011 In Press
Minimum 2 vials per order. 2ml per vial. All clients who have purchased the SP100 Sonoporation platform automatically qualify for additional discounts on future microbubble orders
Interactions of microbubbles with plasmid DNA:
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b. |
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Microscopical demonstration of the interaction of a. SDM202 and b. SDM302 microbubbles with DNA. Pictures were taken on white (left) light and at 518 nm and 605 nm excitation and emission wavelengths, respectively (right) (Nomikou et al., 2011) |
Fluorescence emitted by the DNA-ethidium complex bound on microbubbles attached on cells (Nomikou et al., 2011) |
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Interaction of microbubbles with cells:
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Biotinylated cationic microbubbles attached on cells |
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Direct counts of microbubbles attached on cells (Nomikou et al., 2011) |
Biotinylated cationic microbubbles attached on cells |
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Protocols for SUSPENDED CELLS, ADHERENT CELLS and applications in OPTICELL® are available to clients who have purchased the SONIDEL SP100 platform
MBs2011nua
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