Electrochemotherapy for digital chondrosarcoma

NEPA21 / CUY21 Applications

[Cancer Therapy] Electrochemotherapy for digital chondrosarcoma.

a.     Proximal phalanx of the middle finger is swollen.

b.   Expanding radiolucent mass in the proximal phalangeal bone.

c.     No recurrence was seen even 3 years after treatment.

.

Biopsy specimen.

a) Cells varying in size and shape with nuclear atypia and multivesicular vacuolation of cytoplasm.

b) Two weeks after electrochemotherapy, histological analysis of core needle biopsies revealed 90% tumor cell necrosis

H&E x 200

.

.

Electrode and electroporation.

a. Stainless steel 3cm x 5cm electrodes.

b. Electroporation with two parallel

electrodes placed on opposite

sides of the tumor

Resistance Measurement:     245±101Ω

Voltage: 150V (Electric field strength: 50/cm)

Current:   1.1±0.5A

Pulses:

4 pulses of 250ms (On: 50ms, Off: 200ms)

Or

6 pulses of 167ms (On: 50ms, Off: 117ms)

Gross and microscopic findings of the resected tumor.

a) Gross appearance of marginally resected tumor.

b) Cut surface.

c) Microphotograph of the central portion of the tumor (area c in panel b).

d) Peripheral region (area d in panel b).

H&E x 200

A histological study of the resected tumor showed necrosis at the tumor margin.

Department of Orthopedic Surgery, Shinshu University School of Medicine; Tominaga Shimizu

Department of Regenerative Medicine, Toyama Medical and Pharmaceutical University; Toshio Nikaido

*Journal of Orthopaedic Science, Volume 8, Number 2, Pages 248-251, March 2003

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